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When not to run Agile

People keep asking me whether I’d run all projects using an agile framework such as Scrum. 
 
When I answer “of course not” they often not only expect but gently try to steer me towards an answer that excludes certain type of projects: “You certainly wouldn’t use it for a mission critical system, would you? Or a compliance project? Or an infrastructure project? “
 
Actually, yes! I have used Scrum for business critical systems at a major mobile phone manufacturer, have implemented mission critical systems for a publicly owned European Rail Cargo company, a friend of mine has successfully delivered a compliance project and another one has even developed fighter jet control systems for a European Air Force using scrum. 
 
It’s not about the type of project. It’s not even about the size of your project. It’s about whether you’re willing and able to create a setup that allows agile projects to succeed. To me the rather vague terms of organisational and cultural readiness can be narrowed down to a list of primary show stoppers: 
 
I’d NOT run agile if …